He was born to Ssekabaka Daudi Ccwa and Irene Drussila Namaganda of the Nte clan on the 11-19-1924 and his Royal sisters were Lwantale and Elizabeth Nakabire. His Twin was Musajjatawutta, his Home (Nnyumba) was called Muzibwazaalampanga and his Jjembe was Siimuwuune. He ruled from 1939 to 1969 and his Prime Ministers were Wamala of the Mmamba clan, Michael (Mikayiri) Kawaga Kaggwa who was son to Sir Apollo Kaggwa of the Nseenene clan, Paul (Pawulo) Kavuma of the Ngo clan and Joash Mayanja Nkangi of the Mutima clan. He took over power when he was still a student at Buddo and was only 15 years of age.

He ruled the Kingdom with the help of regents who included Martin Luther Nsibirwa who also the Prime Minister of the Kingdom, Lawuli Kiwanuka who was a judge and Sserwano Woofunira Kkulubya. Later Kawalya Kaggwa took over as the Prime Minister being assisted by the regents. The Kabaka went for studies in the United Kingdom and left the Kingdom in the Hands of regents. He came back to take over leadership of the Kingdom in 1949. His rule saw a lot of interference from the Europeans who wanted him to sign the Buganda agreement of 1900 to which he refused arguing that he cannot sign any Agreement in which he did not attend. This agreement was made during Kabaka Ccwa`s rule when he was also still young and never signed it too. This did not go down well with the Governor Sir Andrew Cohen and it later led to the exiling of Muteesa II like his Grandfather Mwanga II in 1953. He died from England where he was exiled when he was 45 years of age.

Edward Walugembe Mutesa II was enthroned 35th King of Buganda in 1942. Mutesa II did like the way the British had treated his father and right from his enthronement, he demonstrated lack of co-operation with the colonial administrators. Due to his outwardly demonstrated disrespect toward the imperialists, Mutesa II was exiled twice into the United Kingdom hoping that they would 'model' him into the puppet king they wanted him to be, in vain. He even underwent British military training!!

During his reign, many uprisings started around Africa demanding independence from European colonial rulers. Such revolutionary farvour was equally ignited in Buganda and Uganda as a whole, hence the emergency ofpolitical parties in Uganda. As a central figure in Buganda, Mutesa II was continuously targeted hoping that silencing him would quell the uprisings around the country.